vancomycin and Clofarabine Interactions

Interactions between vancomycin and Clofarabine (clofarabine)

vancomycin and clofarabine (Moderate Drug-Drug)

GENERALLY AVOID: Coadministration with drugs that are nephrotoxic may reduce the clearance of clofarabine, which is primarily eliminated by renal excretion.

MANAGEMENT: Drugs that are potentially nephrotoxic (e.g., aminoglycosides, polypeptide and polymyxin antibiotics, vancomycin, amphotericin B, adefovir, cidofovir, tenofovir, foscarnet, cisplatin, gallium nitrate, lithium, mesalamine, certain immunosuppressants, intravenous bisphosphonates, intravenous pentamidine, high intravenous dosages of methotrexate, high dosages of nonsteroidal anti-inflammatory agents) should be avoided during the 5 days of clofarabine administration if possible. Renal function should be evaluated prior to and during therapy, and administration discontinued immediately if substantial increases in creatinine is noted. Clofarabine therapy should be reinstated when the patient is stable and renal function has returned to baseline, possibly at a lower dosage.