valrelease and Luvox cr Interactions

Interactions between valrelease(diazepam) and Luvox cr (fluvoxamine)

diazepam and fluvoxamine (Major Drug-Drug)

GENERALLY AVOID: One study has reported that fluvoxamine significantly decreases the clearance of diazepam and desmethyldiazepam in healthy volunteers. The mean half-life of diazepam increased from 51 hours to 118 hours. The mechanism is inhibition of hepatic CYP450 metabolism. Other benzodiazepines that are metabolized by this route may also be affected.

MANAGEMENT: The manufacturer states that fluvoxamine and diazepam should not be given together. Lorazepam, oxazepam, and temazepam are metabolized by glucuronidation and are not expected to be affected by fluvoxamine.