Drug interactions between Valium and Zoloft
Results for the following 2 drugs: |
|
|---|---|
| Valium (diazepam) | |
| Zoloft (sertraline) | |
Interactions between your selected drugs
diazepam ⇔ sertraline
Applies to: Valium (diazepam) and Zoloft (sertraline)
In a study consisting of 20 healthy male volunteers, pretreatment with sertraline (50 mg/day titrated to 200 mg/day over 10 days) for 22 days was associated with a 32% decrease in the systemic clearance of diazepam (10 mg single intravenous dose) relative to baseline, compared to a 19% decrease relative to baseline for the placebo group. There was no significant difference in the pharmacokinetics of N-demethyldiazepam, a major pharmacologically active metabolite of diazepam, before and after sertraline administration except for the time to reach peak plasma concentration (Tmax), which increased by 23% in the sertraline group and decreased by 19% in the placebo group. The clinical significance of these changes is unknown but should be minimal. However, caution is recommended during concomitant administration, as the risk of using sertraline with other CNS-active drugs has not been systematically evaluated.
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