valacyclovir and Probenecid Interactions

Interactions between valacyclovir and Probenecid (probenecid)

probenecid and valacyclovir (Minor Drug-Drug)

Probenecid may increase the serum concentration of acyclovir through competitive inhibition of renal tubular secretion. Initial dosage adjustments are not usually necessary, but patients should be monitored for acyclovir-related toxicities. Also, probenecid reduces the rate at which valacyclovir is converted to acyclovir. The extent of conversion, however, is unaffected. This interaction is not considered to be clinically significant.