v-cillin-k and Periostat Interactions

Interactions between v-cillin-k(penicillin) and Periostat (doxycycline)

doxycycline and penicillin (Moderate Drug-Drug)

GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.

MANAGEMENT: This combination should be avoided if possible.