v-cillin-k and Benefiber orange creme sugar free Interactions

Interactions between v-cillin-k(penicillin) and Benefiber orange creme sugar free (guar gum)

penicillin and guar gum (Moderate Drug-Drug)

GENERALLY AVOID: Concurrent administration of guar gum may decrease the plasma levels of orally administered penicillins by reducing their absorption. In a study of 10 healthy volunteers administered phenoxymethyl penicillin with and without guar gum, both the peak serum concentration and the area under the serum concentration-time curve of penicillin were found to be significantly reduced by the gum.

MANAGEMENT: The use of guar gum should preferably be avoided during oral penicillin therapy. If these agents must be used together, separating the times of administration by as much as possible may help but has not been studied.