Drug interactions between Uniphyl and Zyrtec
| Results for the following 2 drugs: |
|---|
| Uniphyl (theophylline) |
| Zyrtec (cetirizine) |
Interactions between your selected drugs
theophylline ↔ cetirizine
Applies to:Uniphyl (theophylline) and Zyrtec (cetirizine)
Coadministration with theophylline may decrease the clearance of cetirizine. The mechanism of interaction is unknown. According to the product labeling, a small decrease in the clearance of cetirizine was observed when given with a 400 mg dose of theophylline, and it is possible that larger theophylline doses could have a greater effect. No clinically significant drug interaction has been found with theophylline at a low dose. Steady-state cetirizine (10 mg twice daily for 3.5 days) has also been found to have no significant effects on the pharmacokinetics of theophylline (240 mg intravenously one hour after the last dose of cetirizine) in six healthy volunteers compared to placebo, and vice versa.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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