ultane and Norepinephrine Interactions

Interactions between ultane(sevoflurane) and Norepinephrine (norepinephrine)

norepinephrine and sevoflurane (Major Drug-Drug)

GENERALLY AVOID: The combination of norepinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated anesthetics sensitize the heart to the arrhythmogenic effects of catecholamines.

MANAGEMENT: This combination should be avoided or used very cautiously. If a halogenated anesthetic and norepinephrine must be used together, very low doses of norepinephrine concentrations are recommended and the patient's hemodynamic status should be closely monitored.