ultane and Isocarboxazid Interactions

Interactions between ultane(sevoflurane) and Isocarboxazid (isocarboxazid)

isocarboxazid and sevoflurane (Major Drug-Drug)

CONTRAINDICATED: Anecdotal reports have implicated the concomitant use of general anesthesia and nonselective monoamine oxidase inhibitors (MAOI) as causing hypotension or hypertension. Analysis of these cases suggests that other contributing factors may have been involved (e.g., meperidine and sympathomimetic agents). The safe administration of general anesthetics to patients taking MAOIs has also been reported.

MANAGEMENT: The makers of MAOIs, both selective and nonselective, consider general anesthesia to be contraindicated in patients treated with MAOIs and recommend discontinuing MAOI therapy 10 to 14 days before elective surgery. However, this precaution is generally no longer considered necessary as long as patients are closely monitored during surgery and any adverse or idiosyncratic reactions are promptly managed.