trimpex and Fosphenytoin Interactions

Interactions between trimpex(trimethoprim) and Fosphenytoin (fosphenytoin)

trimethoprim and fosphenytoin (Moderate Drug-Drug)

MONITOR: Trimethoprim may inhibit the CYP450 hepatic metabolism of hydantoins. Serum hydantoin levels and risk of toxicity may be increased. Data are available for phenytoin.

MANAGEMENT: Monitoring for clinical and laboratory evidence of hydantoin toxicity is recommended. Dose adjustments may be necessary. Patients should be advised to notify their physician if they experience symptoms of hydantoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).