Drug interactions between TriCor and Zetia
| Results for the following 2 drugs: |
|---|
| TriCor (fenofibrate) |
| Zetia (ezetimibe) |
Interactions between your selected drugs
fenofibrate ↔ ezetimibe
Applies to:TriCor (fenofibrate) and Zetia (ezetimibe)
MONITOR: Concomitant use of ezetimibe may potentiate the risk of cholelithiasis associated with fenofibrate and other fibrates. Fibrates can increase cholesterol excretion into the bile and cause cholelithiasis. In dogs, administration of ezetimibe for one month increased the concentration of cholesterol in gallbladder bile by 2- to 4-fold, although administration for one year did not result in gallstone formation or any other adverse hepatobiliary effects. In a study of 32 healthy hypercholesterolemic adult subjects, coadministration with fenofibrate (200 mg once daily) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of total ezetimibe by approximately 64% and 48%, respectively. These increases are not considered clinically relevant. Ezetimibe (10 mg once daily) did not significantly affect the pharmacokinetics of fenofibrate.
MANAGEMENT: Caution is advised during coadministration of ezetimibe and fenofibrate. If cholelithiasis is suspected, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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