transderm-nitro and Adalat Interactions

Interactions between transderm-nitro(nitroglycerin) and Adalat (NIFEdipine)

NIFEdipine and nitroglycerin (Moderate Drug-Drug)

MONITOR: Marked, symptomatic orthostatic hypotension has been reported when calcium channel blockers were used in combination with oral controlled-release nitroglycerin.

MANAGEMENT: Dosage adjustments of either class of agents may be necessary. All patients treated with nitroglycerin--with or without calcium channel blockers--should be made aware of possible adverse effects such as dizziness, lightheadedness, and orthostasis, and advised to arise slowly from a sitting or recumbent position.