trandolapril and Ak fluor Interactions

Interactions between trandolapril and Ak fluor (fluorescein)

trandolapril and fluorescein (Moderate Drug-Drug)

MONITOR: Beta-adrenergic blockers (including ophthalmic formulations) and ACE inhibitors may increase the severity and duration of acute anaphylactic reactions to fluorescein injection. In addition, anaphylaxis may be resistant to the usual treatment modalities. The mechanism is unknown.

MANAGEMENT: Patients should be closely monitored for signs of severe, acute hypersensitivity reactions during fluorescein injection, and facilities and equipment for resuscitation, cardiovascular support, and airway management should be immediately available. Clinicians should be aware that larger doses of epinephrine or other adrenergic agents may be required.