tofranil-pm and Bepridil Interactions

Interactions between tofranil-pm(imipramine) and Bepridil (bepridil)

imipramine and bepridil (Major Drug-Drug)

CONTRAINDICATED: Possible QT interval prolongation associated with tricyclic antidepressant drugs and bepridil may be additive. The combination of tricyclic antidepressants and bepridil may result in serious arrhythmias, including ventricular tachycardia, ventricular fibrillation, and torsade de pointes.

MANAGEMENT: The manufacturer considers the concurrent use of other QT interval-prolonging drugs contraindicated with bepridil.