tocainide and Anestacaine Interactions

Interactions between tocainide and Anestacaine (lidocaine)

lidocaine and tocainide (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Lidocaine and tocainide are structurally similar, and each crosses the blood-brain barrier. Their central nervous system side effects, such as agitation, disorientation, and seizures may be additive.

MANAGEMENT: Management consists of cautiously starting patients on tocainide six hours before stopping lidocaine infusions, then starting the next maintenance dose of tocainide six hours after the lidocaine drip has ended. The patient's heart rhythm and clinical response should be monitored during this time.