Interactions between tindamax(tinidazole) and Busodium (butabarbital)
butabarbital and tinidazole (Moderate Drug-Drug)
ADJUST DOSE: Coadministration with a barbiturate may significantly decrease the plasma concentrations and pharmacologic effects of nitroimidazoles. The proposed mechanism is barbiturate induction of nitroimidazole metabolism via hepatic microsomal enzymes. The interaction has been reported with metronidazole and has been attributed to treatment failure in patients with trichomoniasis, giardiasis, or amebiasis given the normally recommended dosages of metronidazole while being treated concomitantly with phenobarbital. Significantly increased clearance and shortened half-life of metronidazole were demonstrated. In many cases, metronidazole dosage had to be doubled or even tripled to achieve a cure. No data are available for tinidazole.
MANAGEMENT: Patients treated concomitantly with a barbiturate may require a higher dosage of metronidazole to achieve a cure. Two- to threefold dosage increases are not uncommon. Pharmacologic response to metronidazole should be monitored and the dosage adjusted as necessary. Given its structural similarities to metronidazole, the same precaution may be applicable during therapy with tinidazole, although clinical data are lacking.
