tindamax and Antabuse Interactions

Interactions between tindamax(tinidazole) and Antabuse (disulfiram)

disulfiram and tinidazole (Moderate Drug-Drug)

GENERALLY AVOID: Use of a nitroimidazole in patients treated with disulfiram may result in confusion and acute psychoses. The exact mechanism of interaction is unknown. The interaction has been reported with metronidazole. In one study, 6 of 29 hospitalized alcoholic patients who were treated with disulfiram (500 mg daily for one month, then 250 mg daily) and metronidazole (750 mg daily for one month, then 250 mg daily) developed acute psychoses or a confusional state, compared to none of the 29 patients receiving disulfiram alone. Five had paranoid delusions and three had visual and auditory hallucinations. Symptoms initially increased following withdrawal of the medications but resolved slowly over two weeks and did not recur when disulfiram alone was restarted. No data are available for tinidazole or vaginally administered metronidazole.

MANAGEMENT: Nitroimidazole therapy should not be administered to patients who have taken disulfiram within the last two weeks.