ticlid and Acova Interactions

Interactions between ticlid(ticlopidine) and Acova (argatroban)

ticlopidine and argatroban (Moderate Drug-Drug)

MONITOR: Although their use often overlaps in clinical practice, the concomitant use of thrombin inhibitors and other anticoagulants may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. A small clinical trial (n=12) reported two minor bleeding events, but no pharmacokinetic interaction or serious adverse events after administration of low-dose argatroban and single-dose warfarin.

MANAGEMENT: Coadministration of thrombin inhibitors and all anticoagulants should be undertaken with caution and only after thorough assessment of risks and benefits. Current guidelines for transitioning from thrombin inhibitors to warfarin may be consulted. Close clinical and laboratory observation for bleeding complications is recommended.