temsirolimus and Coumadin Interactions

Interactions between temsirolimus and Coumadin (warfarin)

warfarin and temsirolimus (Major Drug-Drug)

MONITOR CLOSELY: According to the package labeling, patients receiving temsirolimus in combination with anticoagulation therapy may be at increased risk of developing intracerebral bleeding, including fatal outcomes. The mechanism of interaction has not been described.

MANAGEMENT: Patients receiving anticoagulants should be informed of the increased risk of developing intracerebral bleeding while on temsirolimus.