Drug interactions between Tarceva and Tums E-X 750
Results for the following 2 drugs: |
|
|---|---|
| Tarceva (erlotinib) | |
| Tums E-X 750 (calcium carbonate) | |
Interactions between your selected drugs
calcium carbonate ⇔ erlotinib
Applies to: Tums E-X 750 (calcium carbonate) and Tarceva (erlotinib)
ADJUST DOSING INTERVAL: Concurrent administration of antacids or other agents with acid-neutralizing effects may decrease the oral bioavailability of erlotinib and reduce its concentrations in plasma. The solubility of erlotinib decreases when the pH is over 5, resulting in reduced absorption. Coadministration with omeprazole, a proton pump inhibitor, has been found to significantly reduce the systemic exposure to erlotinib. The interaction has not been studied with antacids.
MANAGEMENT: If concurrent use is necessary, the antacid dose and the erlotinib dose should be separated by several hours.
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