tambocor and Isoptin sr Interactions

Interactions between tambocor(flecainide) and Isoptin sr (verapamil)

verapamil and flecainide (Major Drug-Drug)

MONITOR CLOSELY: Limited data indicate that verapamil and flecainide may have additive cardiodepressant effects. In pharmacokinetic studies with healthy volunteers, there were minor effects on drug plasma concentrations and QRS intervals were prolonged. However, cases of cardiogenic shock, asystole, and death have been reported in patients receiving flecainide and verapamil. Diltiazem may interact with flecainide in a similar manner, although no data are available.

MANAGEMENT: The patient should be monitored closely when either drug is added to the regimen or when dose increases are made.