Interactions between tagamet(cimetidine) and Amiodarone (amiodarone)
amiodarone and cimetidine (Moderate Drug-Drug)
MONITOR: Amiodarone serum concentrations may be increased during concomitant therapy with cimetidine and toxicity could result. The mechanism is not known but may involve inhibition of amiodarone hepatic metabolism or of uptake by hepatocytes. Given the long half-life of amiodarone, it may take several weeks for the full effect of the interaction to be realized.
MANAGEMENT: If amiodarone and cimetidine must be used concomitantly, monitoring of amiodarone serum concentrations is recommended.
