tagamet and Adalat Interactions

Interactions between tagamet(cimetidine) and Adalat (NIFEdipine)

NIFEdipine and cimetidine (Moderate Drug-Drug)

MONITOR: The plasma concentration of some oral calcium channel blockers may be increased by cimetidine. The mechanism is related to inhibition of CYP450 3A4 hepatic metabolism and/or increased gastric pH.

MANAGEMENT: Clinical monitoring of patient response and tolerance is recommended and calcium channel blocker dosage adjustments may be indicated. Dose adjustments may be required. Alternatively, ranitidine is not expected to have clinically significant effects. Patients should be advised to notify their physician if they experience headache, dizziness, orthostasis, or syncope.