Interactions between tagamet(cimetidine) and Acebutolol (acebutolol)
acebutolol and cimetidine (Moderate Drug-Drug)
MONITOR: H2 antagonists such as cimetidine increase plasma concentrations of some oral beta-blockers. The mechanism may be related to inhibition of CYP450 metabolism of hepatically metabolized beta-blockers, and/or inhibition of renal tubular secretion of others. The potential inhibition of CYP450 enzymes by other H2 antagonists (ranitidine, famotidine, nizatidine) is significantly less than that of cimetidine and is not expected to be clinically significant.
MANAGEMENT: Clinical monitoring of patient response and tolerance is recommended when cimetidine is added to or discontinued from a beta-blocker regimen.
