Drug interactions between Sulfazine and Trexall
| Results for the following 2 drugs: |
|---|
| Sulfazine (sulfasalazine) |
| Trexall (methotrexate) |
Interactions between your selected drugs
methotrexate ↔ sulfasalazine
Applies to:Trexall (methotrexate) and Sulfazine (sulfasalazine)
GENERALLY AVOID: Sulfonamides may decrease the renal clearance of methotrexate. Serum levels of free methotrexate and the risk of bone marrow suppression may be increased. Sulfonamides may also displace methotrexate from plasma protein binding sites, which may further increase serum methotrexate levels and the risk of toxicity. Methotrexate toxicity has also been reported in patients receiving low weekly doses.
MANAGEMENT: This combination should be avoided. If patients do receive methotrexate and a sulfonamide, the complete blood count should be monitored periodically, and the clinician should look for signs and symptoms of anemia, leukopenia, megaloblastosis, and even pancytopenia. Patients should be advised to report possible symptoms of toxicity including nausea, vomiting, diarrhea, stomatitis, sore throat, chills, fever, rash, unusual bruising or bleeding, jaundice, dark urine, swelling of the extremities, or shortness of breath to their physician.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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