Interactions between sulfamethoxazole and Cyclosporine (cycloSPORINE)
cycloSPORINE and sulfamethoxazole (Major Drug-Drug)
MONITOR CLOSELY: Sulfonamides may significantly reduce serum cyclosporine concentrations by an unknown mechanism. Allograft rejections have resulted. Hyperkalemia and additive nephrotoxicity has also been reported. The mechanism is unknown. Data are available for intravenous trimethoprim-sulfamethoxazole, intravenous sulfamethazine (no longer marketed), oral sulfadiazine, and sulfasalazine. Oral trimethoprim-sulfamethoxazole reportedly does not affect cyclosporine levels.
MANAGEMENT: Renal function and cyclosporine levels should be closely monitored if these drugs must be used concomitantly.
