Spironolactone Drug Interactions

spironolactone is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with spironolactone.

Major Interactions
Accupril, Aceon, Altace, Aminosyn II 3.5%-Dextrose 25%,Electrolytes,Ca, Aminosyn II 4.25%-Dextrose 20%,Electrolyte,Ca, Aminosyn II 4.25%-Dextrose 25%,Electrolyte,Ca, Aminosyn II with Electrolytes, Aminosyn II with Electrolytes Sulfite-Free, Aminosyn with Electrolytes, Aminosyn with Electrolytes Sulfite-Free, Atacand, Avapro, benazepril, Benicar, candesartan, Capoten, captopril, Cena K, Clinimix E Sulfite Free, Cozaar, Dextrose 10% and Electrolyte No. 48, Diovan, Ed K+10, Effervescent Potassium, enalapril, enalaprilat, eplerenone, eprosartan, Eskalith, Eskalith-CR, fosinopril, Freamine III with Electrolytes, Glu-K, Inspra, Ionosol B and 5% Dextrose, Ionosol MB and 5% Dextrose, Ionosol T and 5% Dextrose, irbesartan, Isolyte E, Isolyte H and 5 % Dextrose, Isolyte M and 5% Dextrose, Isolyte P and 5% Dextrose, Isolyte R and 5% Dextrose, K + Potassium, K+Care ET, K-10, K-8, K-Dur 10, K-Dur 20, K-Effervescent, K-Lor, K-Norm, K-Phos Original, K-Sol, K-Tab, K-vescent, K-Vescent (obsolete), K-Vescent (Potassium Chloride), Kaochlor, Kaochlor S-F, Kaon, Kaon-CI, Kaon-CL 10, Kaon-CL 20%, Kato, Kay Ciel, KCl, KCl-20, Klor-Con, Klor-Con 10, Klor-Con 8, Klor-Con M10, Klor-Con M15, Klor-Con M20, Klor-Con/25, Klotrix, lisinopril, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, losartan, Lotensin, LVP solution with potassium, Lysodren, Mavik, Micardis, Micro-K, Micro-K 10, mitotane, moexipril, Monopril, Neutra-Phos-K, Normosol-M and 5% Dextrose, olmesartan, parenteral nutrition solution w/electrolytes, PC-10, Perchloracap, perindopril, Plasma-Lyte 56, Plasma-Lyte and 5% Dextrose, potassium acetate, potassium acid phosphate, potassium bicarbonate, potassium chloride, potassium chloride extended release, potassium citrate, potassium gluconate, potassium guaiacolsulfonate, potassium perchlorate, potassium phosphate, Prinivil, Procalamine, quinapril, ramipril, Rum-K, Slow-K, sodium biphosphate, telmisartan, Ten-K, Teveten, tizanidine, trandolapril, Travasol with Electrolytes, Travasol with Electrolytes Dual Chamber, Travert 10% and Electrolyte No.2, Travert 5% and Electrolyte No.2, Twin-K, Univasc, Urocit-K, valsartan, Vasotec, Zanaflex, Zestril

Moderate Interactions
40 Winks, A-Hydrocort, A-Methapred, Abilify, Abilify Discmelt, acebutolol, Acetocot, ACTH, ACTH Gel, ACTH-40 HP, ACTH-80, Acthar, Acthar Gel, H.P., Acthrel, Actiq, Actron, Adapin, Adbeon, Adgan, Adlone-40, Adlone-80, Adrenocot, Adrenocot L.A., Advil, Advil Childrens, Advil Junior Strength, Advil Liquigel, Advil Migraine, Advil Pediatric, Aflaxen, Akbeta, alcohol, alcohol, ethyl, aldesleukin, Aler-Dryl, Aler-Tab, Aleve, Aleve Caplet, Aleve Easy Open Arthritis, Aleve Gelcap, Alfenta, alfentanil, All Day Allergy, Allergia-C, Allermax, alprazolam, alprazolam extended release, Altaryl, Ambien, Ambien CR, amifostine, amitriptyline, amoxapine, Anafranil, Anaprox, Anaprox-DS, Anergan 50, Ansaid, Antiflex, Antinaus 50, APO-Go, APO-Go Pen, Apokyn, apomorphine, Aquachloral Supprettes, aripiprazole, Aristocort, Aristocort For Injection, Aristocort Forte, Aristopak, Aristospan Injection, Asendin, Astramorph PF, Atarax, atenolol, Ativan, Avinza, Azmacort, baclofen, Banaril, Banflex, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, Benoject-50, Beta-Phos/AC, Betagan, Betagan C-Cap, betamethasone, betamethasone acet-betamethasone na phosphate, betamethasone sodium phosphate, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, betaxolol ophthalmic, Betimol, Betoptic, Betoptic S, Bextra, bisoprolol, Blocadren, bromfenac, Bubbli-Pred, Budeprion SR, Budeprion XL, budesonide, Buprenex, buprenorphine, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, Butisol Sodium, Bydramine, Bystolic, cabergoline, Calm-Aid, Camptosar, Carbacot, carbamazepine, carbamazepine extended release, Carbatrol, carisoprodol, carteolol ophthalmic, carvedilol, carvedilol extended release, Cataflam, Celebrex, celecoxib, Celestone, Celestone Phosphate, Celestone Soluspan, Celexa, Cell-U-Jec, cetirizine, Childrens Ibuprofen Berry, chloral hydrate, chlordiazepoxide, chlorproMAZINE, chlorproMAZINE extended release, cholestyramine, Cholestyramine Light, citalopram, Clinacort, Clinalog, Clinoril, clomiPRAMINE, clonazepam, Clopine, clorazepate, clorazepate extended release, clozapine, Clozapine Synthon, Clozaril, codeine, codeine phosphate, codeine sulfate, Colocort, Compazine, Compazine Spansule, Compoz Nighttime Sleep Aid, Compro, Coreg, Coreg CR, Corgard, Corlopam, Cort-K, Cortastat, Cortastat 10, Cortastat LA, Cortef, Cortenema, corticorelin, corticotropin, Cortifoam, cortisone, Cortone Acetate, Cortrosyn, cosyntropin, Cotolone, cycloSPORINE, Dalalone, Dalalone D.P., Dalalone L.A., Dalmane, Darvon, Darvon-N, Daypro, Dazidox, De-Sone LA, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decaject, Decaject L.A., Dehydrated Alcohol, Deltasone, Demerol HCl, Denzapine, Dep Medalone 80, Depmedalone, Depo-Medrol, Depo-Predate (obsolete), Depoject-80, Depopred, Desyrel, Desyrel Dividose, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, Dexone, Dexone LA, Dexpak Jr. Taperpak, Dexpak Taperpak, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, diclofenac, diclofenac potassium, diclofenac sodium, diclofenac sodium extended release, diflunisal, dihydrocodeine, Dilaudid, Dilaudid-5, Dilaudid-HP, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diskets, Dizac, Dolobid, Dolophine, Doloral, Doloral Sirop, Dopar, Dostinex, doxepin, doxepin topical, DPH, drospirenone, DurAct, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duralone, Duramorph PF, Dytan, Dytuss, EC-Naprosyn, Effexor, Effexor XR, Elavil, Endep, Endocodone, Entocort, Entocort EC, Epitol, epoprostenol, Equanil, Equetro, escitalopram, ETH-Oxydose, ethanol, Ethyl Alcohol, Ethyol, etodolac, etodolac extended release, FazaClo, Feldene, fenoldopam, fenoprofen, fentanyl, Fentora, Flexoject, Flexon, Flo-Pred, Flolan, Florinef Acetate, fludrocortisone, fluoxetine, fluoxetine extended release, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurazepam, flurbiprofen, fluvoxamine, fluvoxamine extended release, Fortamet, Genahist, Gengraf, Genpril, Geodon, Glucophage, Glucophage XR, Glumetza, Haldol, Haldol Decanoate, haloperidol, haloperidol decanoate, Haltran, Hexadrol, Hexadrol Phosphate, Hydeltra-T.B.A., Hydeltrasol, Hydramine, Hydramine Compound, Hydramine Cough Syrup, hydrocortisone, hydrocortisone acetate, hydrocortisone cypionate, hydrocortisone hemisuccinate, hydrocortisone sodium phosphate, Hydrocortisone Sodium Succinate, Hydrocortone, Hydrocortone Phosphate, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, Hyrexin, Hyzine, Ibu, IBU-200, Ibu-4, Ibu-6, Ibu-8, Ibu-Tab, ibuprofen, Ibuprofen PMR, iloprost, imipramine, imipramine pamoate, Inderal, Inderal LA, Indocin, Indocin SR, indomethacin, indomethacin extended release, Infumorph, InnoPran XL, Invega, Ionsys, irinotecan, Istalol, Kadian, Ken-Jec 40, Kenaject-40, Kenalog-10, Kenalog-40, Kerlone, ketoprofen, ketoprofen extended release, ketorolac, Key-Pred, Key-Pred SP, Klonopin, Klonopin Wafer, labetalol, Larodopa, Leader Naproxen Sodium, Levobunolol, levobunolol ophthalmic, levocetirizine, levodopa, LEVRIX, Lexapro, Librium, Lioresal, Lioresal Intrathecal, Liquid Pred, Lodine, Lodine XL, Lopressor, lorazepam, loxapine, Loxitane, Loxitane C, Loxitane IM, Ludiomil, Luminal, Luvox, Luvox CR, M-Eslon, M-Oxy, M-PREDNISolone, M. O. S., maprotiline, maraviroc, MB-TAB, meclofenamate, Meclomen, Med-Jec-40, Medicort, Medidex, Medidex LA, Medipred, Medralone, Medralone 40, Medralone 80, Medrol, Medrol Dosepak, mefenamic acid, Mellaril, Mellaril-S, meloxicam, Menadol, meperidine, meprobamate, metformin, metformin extended release, Methacort 40, Methacort 80, methadone, Methadose, methdilazine, methocarbamol, Methylcotol, Methylcotolone, Methylpred DP, methylPREDNISolone, methylPREDNISolone acetate, MethylPREDNISolone Dose Pack, methylPREDNISolone sodium succinate, Meticorten, metipranolol ophthalmic, metoprolol, metoprolol extended release, metoprolol succinate, Metoprolol Succinate ER, metoprolol tartrate, midazolam, Midol Extended Relief, Midol IB, Midol Maximum Strength Cramp Formula, Miltown, Mio-Rel, mirtazapine, Mitran, Mobic, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, Motrin, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, MS, MS Contin, MS/S, MSIR, Myolin, nabumetone, nadolol, nalbuphine, Nalfon, Naprelan '375', Naprelan '500', Naprosyn, naproxen, naproxen sodium, Naproxen Sodium DS, naproxen sodium extended release, nebivolol, nefazodone, NeoProfen, Neoral, Nervine, Nightime Sleepaid, Niravam, Norflex, Norflex Injectable, Normodyne, Nu-Med, Nubain, Nuprin, Nytol Caplet, Ocupress, olanzapine, OMS, opium, Opium Deodorized, OptiPranolol, Oramorph SR, Orapred, Orapred ODT, Orasone, Orfro, Ormazine, orphenadrine, orphenadrine extended release, Orphenate, Orudis, Orudis KT, Oruvail, oxaprozin, oxazepam, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, paliperidone, Palladone, Palladone SR, Paral, paraldehyde, Pardryl, Paregoric, paroxetine, paroxetine extended release, paroxetine mesylate, Paxil, Paxil CR, Pediacare Fever, Pediapred, Pentazine, pentazocine, Percolone, Permitil, perphenazine, Pexeva, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, phenobarbital, Phenoject-50, phenylbutazone, pindolol, piroxicam, Ponstel, PP-Cap, Pred-Ject-50, Predacort 50, Predacorten, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, Prednicen-M, Prednicot, prednisoLONE, prednisoLONE acetate, prednisoLONE sodium phosphate, prednisoLONE tebutate, predniSONE, Prelone, Prevalite, Pri-Cortin 50, Primethasone, Primsol, Pro-Med, prochlorperazine, prochlorperazine extended release, Procot, Proleukin, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Proloprim, Promacot, promazine, promethazine, Promethegan, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, propranolol, propranolol extended release, Prorex, prostacyclin, Prozac, Prozac Weekly, Prudoxin, Pulmicort Flexhaler, Pulmicort Nebuamp, Pulmicort Respules, Pulmicort Turbuhaler, Q-Dryl, Q-Dryl A/F, Q-Profen, Quenalin, Questran, Questran Light, quetiapine, quetiapine extended release, Rapiflux, Relafen, Remeron, Remeron SolTab, Remodulin, Rescudose, Restoril, Rezine, Riomet, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, RMS, Robaxin, Robaxin-750, rofecoxib, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, Rufen, Saleto-200, Saleto-400, Saleto-600, Saleto-800, Sandimmune, Sarafem, Scot-Tussin Allergy Relief Formula, secobarbital, Seconal Sodium, Sectral, Selestoject, Selzentry, Serax, Seroquel, Seroquel XR, sertraline, Serzone, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Simply Sleep, Sinequan, Skelex, Sleep Tab II, Sleep Tabs, Sleep-ettes, Sleep-Eze-3, Sleepinal, Solfoton, Solu-Cortef, Solu-Medrol, Solurex, Solurex LA, Soma, Sominex, Sominex Maximum Strength Caplet, Somnicaps, Somnote, Sonata, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), Sparine, Statex, Stelazine, Sterapred, Sterapred DS, Sublimaze, Subutex, sulindac, Surmontil, TAC 3, Tacaryl, Talwin Lactate, Tegretol, Tegretol XR, temazepam, Tenormin, Theraflu Thin Strips Multi Symptom, thioridazine, Thorazine, timolol, timolol hemihydrate ophthalmic, timolol ophthalmic, timolol ophthalmic long-acting, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, TMP, Tofranil, Tofranil-PM, Tolectin, Tolectin 600, Tolectin DS, tolmetin, Toprol-XL, Toradol, Toradol IM, Toradol IV/IM, Total Allergy, Tramacort-D, Trandate, Tranxene SD, Tranxene T-Tab, traZODONE, treprostinil, Triam-A, Triam-Forte, triamcinolone, triamcinolone acetonide, triamcinolone diacetate, triamcinolone hexacetonide, Triamcot, Triaminic Thin Strips Cough & Runny Nose, Triamonide 40, trifluoperazine, Trilafon, Trilog, Trilone, trimethoprim, trimipramine, Trimpex, Tristoject, Trux-adryl, Tusstat, Twilite, U-Tri-Lone, Uni-Tann, Unisom Sleepgels Maximum Strength, Uprima, V-Gan-25, V-Gan-50, valdecoxib, Valium, Valrelease, Valu-Dryl, Vanadom, Vanatrip, venlafaxine, venlafaxine extended release, Ventavis, Versed, Vioxx, Visken, Vistacon, Vistacot, Vistaject-50, Vistaril, Vistaril IM, Vistazine, Vistazine 50, Voltaren, Voltaren-XR, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Xanax, Xanax XR, Xyzal, XYZALL, zaleplon, Zaponex, Zebeta, Zetran, ziprasidone, Zoloft, zolpidem, zolpidem extended release, Zonalon, Zyban, Zyban Advantage Pack, Zyprexa, Zyprexa Zydis, Zyrtec, Zyrtec Hives

Minor Interactions
Acetylsalicylic Acid, Acuprin 81, Adoxa, Adoxa CK, Adoxa TT, Ala-Tet, Alodox, Amigesic, Anaflex, anisindione, apraclonidine ophthalmic, Argesic-SA, Arthritis Pain, Arthropan, ASA, Ascriptin Enteric, Aspergum Cherry, Aspergum Orginal, Aspir-Low, aspirin, aspirin extended release, Aspirin Lite Coat, Aspirin Litecoat, Aspirin Low Strength, Aspirtab, Atapryl, Azilect, Bayer Aspirin, Bayer Aspirin Regimen, Bayer Aspirin Sugar Free, Bayer Aspirin with Calcium, Bayer Childrens Aspirin, Bayer Low Strength, Bayer Plus, Bayer Select Backache Pain Formula, Bismarex, Bismatrol, Bismatrol Maximum Strength, bismuth subsalicylate, Brodspec, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Buffex, Carbex, Cardoxin, Childrens Kaopectate, choline salicylate, Cialis, Coumadin, Declomycin, demeclocycline, dicumarol, Digitek, digitoxin, digoxin, digoxin capsule, Disalcid, Doans Pills, Doans Pills Extra Strength, Doryx, Doxy Lemmon, Doxy-Caps, Doxy-D, doxycycline, doxycycline hyclate, doxycycline monohydrate, Dynacin, Easprin, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Eldepryl, Empirin, Emsam, Emtet-500, Entaprin, Entercote, Extra Strength Bayer, Fasprin, furazolidone, Furoxone, Genacote, Gennin-FC, Genprin, glycyrrhiza, Halfprin, Iopidine, isocarboxazid, Jantoven, Jumex, K-Pek, Kao-Tin Bismuth Subsalicylate Formula, Kaopectate, Kaopectate Anti-Diarrheal Upset Stomach Reliever, Kaopectate Extra Strength, Kapectolin (New Formula), Lanoxicaps, Lanoxin, licorice, linezolid, Litecoat Aspirin, Low Dose ASA, Maalox Total Stomach Relief, Magan, magnesium salicylate, Marplan, Marthritic, Matulane, Maximum Strength Stress, Minitabs, Minocin, Minocin PAC, minocycline, minocycline extended release, Miradon, Mobidin, Mono-Gesic, Monodox, MST, Myrac, Nardil, Norwich Aspirin, Nuprin Backache Caplet, Oracea, Oraxyl, oxytetracycline, Panmycin, Parnate, Peptic Relief, Pepto-Bismol, Pepto-Bismol Maximum Strength, Periostat, phenelzine, phenyl salicylate, Pink Bismuth, procarbazine, rasagiline, Rexolate, Robitet 500, Salflex, salicylamide, salsalate, Salsitab, selegiline, Selgene, Sloprin, sodium salicylate, sodium thiosalicylate, Solodyn, St. Joseph Aspirin, St. Joseph Aspirin Adult Chewable, St. Joseph Aspirin Adult EC, Stanback Analgesic, Stress Maximum Strength, Sumycin, tadalafil, Terramycin, Tetracap, Tetracon, tetracycline, Therapy Bayer, tranylcypromine, Tri-Buffered Aspirin, Tusal, Vectrin, Vibra-Tabs, Vibramycin, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin Monohydrate, warfarin, YSP Aspirin, Zelapar, Zero-Order Release, Zorprin, Zyvox

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