Interactions between selegiline-hydrochloride(selegiline) and Carbetapentane (carbetapentane)
selegiline and carbetapentane (Major Drug-Drug)
GENERALLY AVOID: Labelings for products containing carbetapentane state that the drug should not be used in combination with monoamine oxidase inhibitors (MAOIs). No data are available regarding a potential interaction. However, serious and fatal reactions have been associated with another cough suppressant, dextromethorphan, during coadministration with MAOIs. Dextromethorphan is a weak serotonin reuptake inhibitor whose serotonergic activity may be enhanced by MAOIs. The result is an increased risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors and characterized by symptoms such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
MANAGEMENT: Products containing carbetapentane should not be used concurrently with MAOIs or for 14 days after stopping treatment with an MAOI.
