selegiline-hydrochloride and Bupropion 24 hour extended release Interactions

Interactions between selegiline-hydrochloride(selegiline) and Bupropion 24 hour extended release (buPROPion)

buPROPion and selegiline (Major Drug-Drug)

CONTRAINDICATED: According to the manufacturer, the acute toxicity of bupropion may be potentiated by coadministration of monoamine oxidase inhibitors (MAOIs). The mechanism of interaction has not been described.

MANAGEMENT: Concurrent use of bupropion with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, procarbazine) is considered contraindicated. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with bupropion.