Drug interactions between Rythmol SR and warfarin
Results for the following 2 drugs: |
|
|---|---|
| Rythmol SR (propafenone) | |
| warfarin | |
Interactions between your selected drugs
warfarin ⇔ propafenone
Applies to: warfarin and Rythmol SR (propafenone)
MONITOR: Propafenone may increase anticoagulant serum concentrations and effects. The mechanism is inhibition of CYP450 2C9 metabolism. In healthy subjects, warfarin plasma concentrations increased 39% and prothrombin time increased 25% when propafenone was taken concomitantly.
MANAGEMENT: Management consists of monitoring PT or INR until a stable and safe anticoagulant dosage is found. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
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