ritonavir and Aptivus Interactions

Interactions between ritonavir and Aptivus (tipranavir)

ritonavir and tipranavir (Major Drug-Drug)

MONITOR CLOSELY: Coadministration of tipranavir with ritonavir 200 mg has been associated with cases of clinical hepatitis and hepatic decompensation including some fatalities.

MANAGEMENT: Close monitoring of hepatic function is recommended in patients treated with tipranavir and ritonavir. Particular caution is warranted in patients with chronic hepatitis B or C coinfection, as they may have an increased risk of hepatotoxicity. Patients should be advised to notify their physician if they experience signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.