rezulin and Adalat cc Interactions

You searched for interactions between

• rezulin (troglitazone)
• Adalat cc (NIFEdipine)

Interaction(s) found:

NIFEdipine and troglitazone (Moderate Drug-Drug)

MONITOR: Coadministration with troglitazone may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is accelerated clearance due to induction of CYP450 3A4 activity by troglitazone.

MANAGEMENT: Caution is advised if troglitazone must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever troglitazone is added to or withdrawn from therapy.