rezulin and Abilify Interactions

You searched for interactions between

• rezulin (troglitazone)
• Abilify (aripiprazole)

Interaction(s) found:

troglitazone and aripiprazole (Moderate Drug-Drug)

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the product labeling, administration of aripiprazole (30 mg once a day) with the potent CYP450 3A4 inducer carbamazepine (200 mg twice a day) resulted in an approximately 70% decrease in the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of aripiprazole and its active metabolite, dehydro-aripiprazole.

MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the aripiprazole dosage adjusted as necessary. The manufacturer recommends that aripiprazole dosage be doubled when carbamazepine is added to therapy, and additional dosage increases be based on clinical evaluation. No dosage recommendations are available for concomitant administration with other CYP450 3A4 inducers.