Interactions between restoril(temazepam) and Acetazolamide extended release (acetaZOLAMIDE)
acetaZOLAMIDE and temazepam (Moderate Drug-Drug)
MONITOR: Benzodiazepines may counteract the beneficial effects of acetazolamide in preventing altitude sickness by inhibiting respiratory responses to hypoxia. The medical team that accompanied the China-Japan-Nepal Friendship Expedition to Mount Everest in 1988 reports severe hypoventilation in some climbers when acetazolamide and triazolam were given together. One affected climber could be ordered to breath regularly, but repeatedly 'forgot' to continue breathing. This syndrome has been referred to as 'Ondine's curse'.
MANAGEMENT: Caution is recommended if a CAI and a benzodiazepine must be used together. Until more information is available, it may be prudent to avoid the concurrent use of triazolam and acetazolamide at extreme altitudes.
