relenza and Influenza virus vaccine live trivalent Interactions

Interactions between relenza(zanamivir) and Influenza virus vaccine live trivalent (influenza virus vaccine, live, trivalent)

zanamivir and influenza virus vaccine, live, trivalent (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Antiviral agents that are active against influenza A and/or B viruses may conceivably interfere with the immunogenicity of live influenza virus vaccine by inhibiting the replication of vaccine virus. However, the potential for interaction has not been evaluated.

MANAGEMENT: Live influenza virus vaccine should preferably not be administered until at least 48 hours after the cessation of antiviral therapy. Antiviral agents should not be administered until two weeks after immunization with live influenza virus vaccine unless medically indicated. The product labeling for zanamivir recommends waiting 24 hours after cessation of the drug before administration of live influenza virus vaccine.