raloxifene and Divigel 0 5 mg packet Interactions

Interactions between raloxifene and Divigel 0 5 mg packet (estradiol)

estradiol and raloxifene (Moderate Drug-Drug)

GENERALLY AVOID: The concurrent use of raloxifene and systemic estrogen or hormone replacement therapy has not been evaluated in prospective clinical trials. Safety and efficacy of this combination are unknown. However, concomitant use of vaginal estrogen preparations was allowed in clinical trials for treatment of atrophic vaginal symptoms if necessary.

MANAGEMENT: Due to the lack of clinical data, use of raloxifene with systemic estrogens is not recommended.