rabeprazole and Lapatinib Interactions

Interactions between rabeprazole and Lapatinib (lapatinib)

rabeprazole and lapatinib (Moderate Drug-Drug)

MONITOR: Coadministration with lapatinib may increase the plasma concentrations of drugs that are substrates of the CYP450 2C8 isoenzyme, CYP450 3A4 isoenzyme, and/or P-glycoprotein efflux transporter. The mechanism is decreased clearance via these routes due to inhibition by lapatinib.

MANAGEMENT: Caution is advised if lapatinib must be used concurrently with medications that are substrates of the CYP450 2C8 isoenzyme, CYP450 3A4 isoenzyme, and/or P-glycoprotein efflux transporter, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever lapatinib is added to or withdrawn from therapy.