rabeprazole and Indinavir Interactions

Interactions between rabeprazole and Indinavir (indinavir)

indinavir and rabeprazole (Moderate Drug-Drug)

MONITOR: Proton pump inhibitors may decrease the gastrointestinal absorption of indinavir. The proposed mechanism is a pH-dependent reduction in drug dissolution or absorption. The interaction has been reported specifically with omeprazole but may be expected with other proton pump inhibitors based on their common pharmacologic action.

MANAGEMENT: Caution is advised during the chronic use of these drugs with indinavir due to the risk of treatment failure and emergence of drug resistance associated with subtherapeutic levels of indinavir. Patients should be monitored for altered antiviral effectiveness.