rabeprazole and Atazanavir Interactions

Interactions between rabeprazole and Atazanavir (atazanavir)

rabeprazole and atazanavir (Major Drug-Drug)

GENERALLY AVOID: Concurrent use of proton pump inhibitors may decrease the oral bioavailability of atazanavir and substantially reduce its concentrations in plasma. Atazanavir solubility decreases with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of proton pump inhibitors is not recommended in patients treated with atazanavir.