rabeprazole and Aerolate sr Interactions

Interactions between rabeprazole and Aerolate sr (theophylline)

theophylline and rabeprazole (Moderate Drug-Drug)

MONITOR: Proton pump inhibitors may increase the rate of theophylline absorption from sustained-release formulations. Chronic use of proton pump inhibitors produce sustained hypochlorhydria, which may enhance peristalsis in the small intestine and antiperistalsis in the proximal colon where theophylline is absorbed.

MANAGEMENT: In patients treated with proton pump inhibitors, the possibility of an enhanced pharmacologic response to sustained-release theophylline should be considered. Patients should be closely monitored for development of toxicity, particularly those with theophylline levels in the upper range of normal. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.