quinidine and Amiodarone Interactions

Interactions between quinidine and Amiodarone (amiodarone)

amiodarone and quinidine (Major Drug-Drug)

MONITOR CLOSELY: Amiodarone may increase serum quinidine concentrations and exacerbate quinidine-induced QT interval widening by competing for protein binding sites and inhibiting hepatic metabolism of quinidine. Torsades de pointes may occur.

MANAGEMENT: A 30 to 50% reduction in quinidine dosage is recommended for patients receiving amiodarone. Patients should be closely monitored for signs of quinidine toxicity, and serum levels, electrolyte levels, and ECG should also be monitored. Patients should be advised to promptly report any early symptoms of toxicity including nausea, vomiting, diarrhea, tinnitus, hearing loss, visual disturbances, dizziness, headache, and confusion.