questran and Cardoxin Interactions

Interactions between questran(cholestyramine) and Cardoxin (digoxin)

cholestyramine and digoxin (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Cholestyramine may decrease the absorption and possibly the enterohepatic recirculation of digoxin. Digoxin serum concentrations and pharmacologic effect may be reduced.

MANAGEMENT: Cholestyramine should be administered at least eight hours before or after a dose of digoxin. It may be prudent to monitor patients for altered clinical response and to monitor digoxin levels. Patients should be advised to notify their physician if they experience worsening of their heart symptoms. Conversely, patients should be monitored for digoxin toxicity after discontinuation of cholestyramine.