questran and Anisindione Interactions

Interactions between questran(cholestyramine) and Anisindione (anisindione)

cholestyramine and anisindione (Moderate Drug-Drug)

MONITOR: Cholestyramine may decrease the absorption and increase the elimination of warfarin or other oral anticoagulants. Anticoagulant effect may be reduced. However, cholestyramine also may impair vitamin K absorption, and the anticoagulant effect of warfarin may be enhanced in some patients. Starting or stopping cholestyramine in the presence of chronic oral anticoagulant therapy may lead to altered PT or INR.

MANAGEMENT: Warfarin or other oral anticoagulants should be administered at least one hour before or four to six hours after cholestyramine. The INR or PT should be closely monitored. Patients should be advised to promptly report any signs of bleeding (e.g., pain, swelling, headache, dizziness, weakness, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).