Interactions between questran-light(cholestyramine) and Baycol (cerivastatin)
cholestyramine and cerivastatin (Moderate Drug-Drug)
ADJUST DOSING INTERVAL: When administered concomitantly, cholestyramine decreases the bioavailability and peak plasma concentration of cerivastatin, most likely due to adsorption of the statin to the resin. In one study, the bioavailability was reduced by 21% and the peak plasma concentration by 41% under fasting conditions. Separating their administration times by 1 to 5 hours attenuated the effect, resulting in a reduction of 8% to 16% in the bioavailability, depending on length of time between the doses.
MANAGEMENT: If simultaneous therapy with both agents is desired, cerivastatin should be administered several hours after the bile acid binding resin.
