pyrimethamine and Methotrexate sodium preservative free Interactions

Interactions between pyrimethamine and Methotrexate sodium preservative free (methotrexate)

methotrexate and pyrimethamine (Moderate Drug-Drug)

MONITOR: Coadministration of pyrimethamine with antifolate or myelosuppressive agents may increase the risk of bone marrow depression. The mechanism is additive antifolate effects.

MANAGEMENT: Periodic clinical and laboratory monitoring for folic acid deficiency and/or bone marrow depression is advisable during concurrent use.