pyrimethamine and Azulfidine Interactions

Interactions between pyrimethamine and Azulfidine (sulfasalazine)

pyrimethamine and sulfasalazine (Moderate Drug-Drug)

MONITOR: Coadministration of pyrimethamine in doses exceeding 25 mg per week with trimethoprim or sulfonamides may increase the risk of megaloblastic anemia and pancytopenia. The proposed mechanism is additive antifolate effects.

MANAGEMENT: Periodic clinical and laboratory monitoring for signs of folic acid deficiency and hematologic changes is advisable.