pseudoephedrine and Dihydroergotamine Interactions

Interactions between pseudoephedrine and Dihydroergotamine (dihydroergotamine)

dihydroergotamine and pseudoephedrine (Moderate Drug-Drug)

GENERALLY AVOID: Ergot alkaloids may cause a significant increase in blood pressure when combined with peripheral or central vasoconstrictors. The mechanism is an additive or synergistic vasoconstriction due to the alpha adrenergic agonist activity of ergot alkaloids.

MANAGEMENT: The use of dihydroergotamine injection or nasal spray with vasoconstrictive agents is not recommended and other ergot alkaloids should be administered with caution. Clinical monitoring of patients response and tolerance, including measurements of vital signs and monitoring for excessive vasoconstriction, is recommended if these products are used in combination. Patients should be advised to notify their doctor if they experience numbness, tingling, or cyanosis in the extremities, muscle pains, weakness, or chest pain or tightness.