pseudoephedrine and Citrate phos dex Interactions

Interactions between pseudoephedrine and Citrate phos dex (sodium citrate)

pseudoephedrine and sodium citrate (Moderate Drug-Drug)

MONITOR: Alkalization of the urine decreases the urinary excretion increases the elimination half-life of ephedrine, pseudoephedrine, and related drugs. According to one report, an increase in pH from 5.1 to 7.1 increased the half-life of pseudoephedrine from 5 to 16 hours. Toxicity from long-term use of pseudoephedrine has been demonstrated in patients with persistently alkaline urine.

MANAGEMENT: Patients should be monitored for toxic effects such as tremor, anxiety, insomnia, irritability, or nervousness. Dosage reductions may be required.