Drug interactions between Prostigmin and Quelicin
| Results for the following 2 drugs: |
|---|
| Prostigmin (neostigmine) |
| Quelicin (succinylcholine) |
Interactions between your selected drugs
neostigmine ↔ succinylcholine
Applies to:Prostigmin (neostigmine) and Quelicin (succinylcholine)
MONITOR: Acetylcholinesterase inhibitors may prolong and/or enhance the muscle relaxation effects of succinylcholine by blocking the activity of plasma cholinesterase, the enzyme responsible for the hydrolysis of succinylcholine. Prolonged neuromuscular blockade and respiratory depression may occur.
MANAGEMENT: It may be appropriate to discontinue acetylcholinesterase inhibitor therapy for a few days before the procedure depending on the needs of the patient. Otherwise, the patient should be monitored closely for increased pharmacologic effects of succinylcholine. Peripheral nerve stimulators are recommended for accurate assessment of neuromuscular blockade in patients who have been taking pyridostigmine.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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