Drug interactions between Prosom and Prozac
| Results for the following 2 drugs: |
|---|
| Prosom (estazolam) |
| Prozac (fluoxetine) |
Interactions between your selected drugs
fluoxetine ↔ estazolam
Applies to:Prozac (fluoxetine) and Prosom (estazolam)
MONITOR: Several studies have suggested that the effects of benzodiazepines, particularly their effects on psychomotor performance, may be increased by fluoxetine. The mechanism may be related to additive CNS depressant effects and/or inhibition of CYP450 2C19 and/or 3A4 benzodiazepine metabolism by fluoxetine. The clinical implications are uncertain, but effects may be more pronounced in the elderly.
MANAGEMENT: Patients should be monitored for excessive CNS depression and psychomotor impairment. Dose reductions may be required. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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